Dr. Hsiao-Han Chang is an Assistant Professor at National Tsing Hua University’s Institute of Bioinformatics and Structural Biology in Hsinchu City, Taiwan. She was formerly a Research Associate at Harvard T.H. Chan School of Public Health’s Center for Communicable Disease Dynamics, where she worked with CrisisReady’s Caroline Buckee and Marc Lipsitch, both Professors of Epidemiology at HSPH. Prior to this role, Hsiao-Han was at the department of Organismic and Evolutionary Biology at Harvard University, where she obtained her PhD with Daniel Hartl and John Wakeley.
Her doctoral research focused on genomic variation and evolution of the human malaria parasite Plasmodium falciparum. She is very interested in applying population genetic tools to pathogens and linking the results to infectious disease epidemiology and control. Her malaria work includes inferring migration patterns across geographic scales, developing statistical tools to elucidate infection history, and modeling the impact of heterogeneous duration of infection on selection efficiency. In addition, she is designing serodiagnostic tools for Zika virus, and studying natural selection and population structure of dengue virus and MRSA.
Dr. Chang is also a seed grant recipient at CrisisReady. She helped organize and run CrisisReady’s regional workshop in Teepee, Taiwan, which brought together researchers from National Tsing Hua University and public health officials in the country to discuss the role of mobility data in public health response.
RESEARCH
- Worby, C.J., Chang, HH. Face mask use in the general population and optimal resource allocation during the COVID-19 pandemic. Nat Commun 11, 4049 (2020). https://doi.org/10.1038/s41467-020-17922-x
- Chang, H.-H., Cohen, T., Grad, Y. H., Hanage, W. P., O’Brien, T. F., & Lipsitch, M. (2015). Origin and proliferation of multiple-drug resistance in bacterial pathogens. Microbiology and Molecular Biology Reviews, 79(1), 101–116. https://doi.org/10.1128/mmbr.00039-14
- Daniels, R. F., Schaffner, S. F., Wenger, E. A., Proctor, J. L., Chang, H.-H., Wong, W., Baro, N., Ndiaye, D., Fall, F. B., Ndiop, M., Ba, M., Milner, D. A., Taylor, T. E., Neafsey, D. E., Volkman, S. K., Eckhoff, P. A., Hartl, D. L., & Wirth, D. F. (2015). Modeling malaria genomics reveals transmission decline and rebound in Senegal. Proceedings of the National Academy of Sciences, 112(22), 7067–7072. https://doi.org/10.1073/pnas.1505691112
- Park, D. J., Lukens, A. K., Neafsey, D. E., Schaffner, S. F., Chang, H.-H., Valim, C., Ribacke, U., Van Tyne, D., Galinsky, K., Galligan, M., Becker, J. S., Ndiaye, D., Mboup, S., Wiegand, R. C., Hartl, D. L., Sabeti, P. C., Wirth, D. F., & Volkman, S. K. (2012). Sequence-based association and selection scans identify drug resistance loci in the plasmodium falciparum malaria parasite. Proceedings of the National Academy of Sciences, 109(32), 13052–13057. https://doi.org/10.1073/pnas.1210585109
- Lee, C.-S., Wang, R. W., Chang, H.-H., Capurso, D., Segal, M. R., & Haber, J. E. (2015). Chromosome position determines the success of double-strand break repair. Proceedings of the National Academy of Sciences, 113(2). https://doi.org/10.1073/pnas.1523660113